| abstract |
REFERS TO PROCESS FOR THE SYNTHESIS OF DERIVATIVES OF THE 3-AMINO-TETRAHYDROFURAN ACID OF FORMULA (I), WHERE D IS A BICYCLE RING SYSTEM OF FORMULA (II), WHERE K1 AND K4 ARE INDEPENDENTLY -CH2, -CHR7a -CR7-7c O -C (O); EACH R2 AND R3 ARE INDEPENDENTLY -CH2, -CHR8a, -CR8-8c OR -C (O); X IS NR1; A1 IS NO CR10; A2 IS NO CR11; A3 IS NO CR12; R3 IS HO (C1-C3) ALKYL; M IS THIOPHENE THAT IS JOINED TO THE CARBONYL OF (I), IN POSITION 2 AND IS SUBSTITUTED IN POSITION 5 WITH R2 AND OPTIONALLY ALSO WITH R6. AMIDES OF THE ACID (S) -3 - [(5-BROMO-THIOFEN-2-IL) -CARBONYLAMINE] -N- (3-METHYL-2,3,4,5-TETRAHIDRO-1H-BENZO [d] are selected AZEPIN-7-IL) -TETRAHYDROFURAN-3-CARBOXYLICO, N- {3- [4- (5-CYANIMIN- [1,4] OXAZEPAN-4-IL) -PHENYLCARBAMOYL] -TETRAHYDROFURANE-3-IL} -AMIDE OF ACID (S) -5-CHLORO-THIOFENO-2-CARBOXILICO, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS PRESENT AN INHIBITING EFFECT ON FACTOR Xa AND INHIBITOR ON SERIN PROTEASAS PRESENTING ANTI-THROMBOTIC ACTIVITY |