| abstract |
REFERRING TO COMPOUNDS DERIVED FROM 2,3,4,9-TETRAHIDRO-1H-CARBAZOL DE FORMULA (I) WHERE AND IS (a), (b), (c), AMONG OTHERS, WHERE R3 AND R4 ARE EACH H , AMINO, -C (= O) -O-ALKYL (C1-C6), AMONG OTHERS; R5 IS H, (C1-C6) ALKYL OR (C3-C6) CYCLOALKYL; R6 IS H, CN, NO2, NH2, ALCOXY (C1-C6), AMONG OTHERS; Q IS ALKYLENE (C1-C6), ALKYLIDENE (C1-C6), AMONG OTHERS; m IS 0 TO 3; n IS FROM 1 TO 3; R1 IS H, ALKYL (C1-C6), CYCLOALKYL (C3-C6), -S (= O) 2-ALKYL (C1-C6), AMONG OTHERS; R2 IS HETERO CYCLOALKYL (C3-C6), HETERO CYCLOALKYL (C3-C6) -ALKYL (C1-C4), ARYL (C6-C10), AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: N- [2- (CYCLOPROPYLAMINO) -2-OXOETHYL] -N, 9-DIMETHYL-3- (TETRAHYDRO-2H-PYRAN-4-IL) -2,3,4,9-TETRAHYDRO-1H- CARBAZOL-6-CARBOXAMIDE, N-ETHYL-N- [2- (ETHYLAMINE) -2-OXOETHYL] -9-METHYL-3- (TETRAHYDRO-2H-PYRAN-4-IL) -2,3,4,9- TETRAHYDRO-1H-CARBAZOL-6-CARBOXAMIDE, N-CYCLOPROPYL-2- (1- (9-METHYL-3- (TETRAHYDRO-2H-PYRAN-4-IL) -2,3,4,9-TETRAHYDRO-1H- CARBAZOL-6-CARBONYL) AZETHYDIN-3-IL) ACETAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE LIGANDS OF THE CANNABINOID RECEPTOR CB1 BEING USEFUL IN THE TREATMENT OF PAIN, MULTIPLE SCLEROSIS, HUNTINGTON KOREA, ALZHEIMER'S DISEASE |