| abstract |
IT REFERS TO A COMPOUND OF FORMULA I, WHERE: A IS A RING SELECTED FROM PHENYL, OXAZOLYL, ISOXASOLIL, AMONG OTHERS; B IS A SINGLE CYCLIC ARYL OR C5-C6 SINGLE CYCLE ARYL OPTIONALLY SUBSTITUTED; R1 AND R3 ARE, INDEPENDENTLY OF IF, H, C1-C4 ALKYL, C1-C4 HALOALKYL, AMONG OTHERS; R2 IS C1-C6 ALKYL, C2-C6 ALKYL, C2-C6 ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N2- (3-FLUOROPYRIDIN-4-IL) -N4-ISOPROPYL-6-PHENYL-1,3,5-TRIAZIN-2,4-DIAMINE, N2-ISOPROPYL-N4- (2-MORPHOLINOPYRIDIN-4 -IL) -6-PHENYL-1,3,5-TRIAZIN-2,4-DIAMINE, INCLUDING OTHER. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUND IS AN INHIBITOR OF MUTANT IDH2 (ISOCITRATE DEHIDROGENASE 2 MITROCONDRIAL), WHICH IS USEFUL IN THE TREATMENT OF CANCER. |