| abstract |
Refers to a compound of formula I, where: W is N, C-H, or C-F; X is hydrogen, halogen, -CN, among others; Y is hydrogen, optionally substituted alkyl, among others; Z is alkyl, carbocyclyl, among others. Preferred compounds are: 4- (2- (4-aminopiperidin-1-yl) -1-methyl-6-oxo-5-p-toluyl-1,6-dihydropyrimidin-4-yl) benzonitrile; 4- (2- (4-aminopiperidin-1-yl) -5- (4-methoxyphenyl) -1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl) benzonitrile; among others. It also refers to a pharmaceutical composition and a method of treatment. These compounds are inhibitors of lysine-specific demethylase 1, being useful in the treatment of cancer. |