| abstract |
It refers to bicyclic compounds derived from dihydroquinoline-2-one of formula I in which R1, R2, R3, R4, R5, R8, R9, R10 are H, alkyl, haloalkyl, cycloalkyl, halocycloalkyl; R6, R7, R12, are H, halogen, alkyl, haloalkyl, cycloalkyl, among others; A1 is N or CR13; A2 is NR14, among others; A3 is N or CR17; n is zero, 1 or 2. Said compounds are useful for therapy or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism, among others. Among the preferred compounds we have the following: (rac) -N- [4- (1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl) -5,6,7,8 -tetrahydro-isoquinolin-8-yl) propionamide; (rac) -N- [4- (1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl) -5,6,7,8-tetrahydroisoquinolin-8-yl) ethanesulfonamide; among others. |