| abstract |
The invention relates to isobenzofuran derivatives of general formula (I) in which A is selected from (1), (2), (3); n is sc of 2, 3, or 4; m has an sc value of 0 or 1; R 4 is hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, 2-furylmethyl or 2-phenoxyethyl; D is a linker group selected from straight chain C 1-4 alkylene groups; B is a group e selected from among the groups of formulas (II), (III) and (IV) wherein R 5 and R 6 are each independently hydrogen or a methoxy group; R8 and R9 are each selected independently from hydrogen, halogen, C1-4alkyl and COOH; or two of the groups R 5, R 6 and R 7 are joined together to form a bridge -O- (CH 2) p-O-, wherein p is 1 or 2; or B is 5-pyrrolo [3.2-4] -1H-quinolin-3-yl; Ar is phenyl optionally substituted with halogen or trifluoromethyl; and their enantiomers and pharmaceutically acceptable acid addition salts, as well as pharmaceutical compositions containing them and their use in therapy. Compounds bind strongly to the 5-HT 1A receptor. PL PL PL PL PL PL |