http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PL-436105-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1925630369470a4aa51694f659e2c4b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72fdbccb2ebf98173e826a3e1a4f2b1c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L59-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L23-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L81-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L83-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L69-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L67-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D69-02 |
| filingDate | 2020-11-27^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5af4d5806e7cfc5ff4a0a96fa54685d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd52255a57e461ef9c63d4cc8616029f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aabde336b399a3d625b8e0eee950c270 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51eb4b8cfd3696ffe0fe9f2be1cc1eec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86d6fc1480e3a2044528b9e9d0eaaa9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_125f510ace416cf8084a4e07fa77d699 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea75e066caa8e42a868962e613526d91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84ef70a2907c55cd99a7c2497972067a |
| publicationDate | 2021-07-05^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PL-436105-A1 |
| titleOfInvention | Organic material with pore-forming, anti-inflammatory and anticoagulant properties and the method of its preparation |
| abstract | The subject of the application is an organic material with pore-forming, anti-inflammatory and anticoagulant properties, and a method of its preparation consisting in introducing a polar solvent under an inert gas atmosphere and an acid selected from sulfuric acid VI, hydrochloric acid or acetic acid in proportions from 2 ÷ 0.002 to 7 ÷ 0.002, and then, 4- (diphenylamino) benzaldehyde in an amount from 0.2 g to 0.7 g and 1,3-indandione in an amount from 0.01 g to 50 mL of the mixture thus formed are added. 0.08 g and stirred until a homogeneous mixture was obtained, then the suspension was washed with inert gas for at least 5 minutes, heated to reflux under an inert gas atmosphere, and stirred intensively at 100 - 1000 rpm for every at least 18 hours. After the mixing process, the resulting mixture is cooled to a temperature of 20 to 35 ° C and subjected to column chromatography in the SiO2 bed and in the mobile phase of a mixture of hexane and methylene chloride, in the amount of hexane from 0.5 to 2 times the volume of the mixture, and methylene chloride from 0 , 5 to 2 times the volume of the reaction mixture. It is then dried under vacuum for at least 20 hours to constant weight and then recrystallized from chloroform. The product after recrystallization from chloroform (recrystallization) is placed in a homogenizer and the base is added in the form of: polypropylene (PP) or polyurethane (PU) or poly (ethylene terephthalate) (PET) or polycarbonate (PC) or polyoxymethylene (POM) or polysulfone (PSU) ) or silicone or a fluoropolymer, preferably poly (tetrafluoroethylene) (PTFE) or polyvinylidene fluoride (PVDF) or a copolymer of tetrafluoroethylene and hexafluoropropylene (FEP), in a base-recrystallization ratio from 50-2 to 5000-2, and then mixed until obtaining homogeneous mixture and dried for at least 20 hours at a temperature of 80 - 110 ° C, then the material is extruded on a linear head in the form of a string, or on a cross head in the form of a tube, or on a flat head in the form of a foil, in the next stage the process of immobilization of fondaparinux to the steric structure of the material obtained in this way ensures its content in the material in the base-fondaparinux ratio from 80 ÷ 1 to 1200 ÷ 1, wt aki the way that after initial cooling in a bath containing a supersaturated aqueous solution of fondaparinux to a temperature of ± 30 ° C from the plastic transition temperature, it is stretched on calenders so as to obtain an elongation of 5-20 times, which results in the formation of micropores in which fondaparinux is immobilized. |
| priorityDate | 2020-11-27^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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