| abstract |
The invention relates to a method for the prevention and treatment of a disease associated with angiogenesis. The method for the prevention and treatment of a disease associated with angiogenesis according to the invention consists in administering an amount of 0.1 ... 2000 mg, preferably 0.5, by the oral, intravenous, intramuscular, subcutaneous, intraperitoneal route. .500 mg, more preferably 1 ... 200 mg, in a daily dose of 0.01 ... 100 mg / kg body weight, 1 ... 4 times per day, of a cyclooxygenase-2 inhibitor, which has a IC50 cyclooxygenase-2 of less than 0.2 μM, a cyclooxygenase-2 inhibition selectivity vs. inhibition of acylooxygenase-1 of at least 50, more preferably at least 100, or having a IC 50 of cyclooxygenase-1 greater than 1 μM, and more preferably 10 μM, selected from a compound of formula I. |