http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RS-51605-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 2003-10-21^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_650673e59b62a050ce66c4d24194628e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5271f83c7293a6ca03552b938d7543a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d40c129865b9b550a654c81d56375de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c6b20ffc0a201e3179b83f2d889d57d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51c2ac53c549d83fca2c9e15326da11c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b7a4863d0c9a0b1498faaddcb407c9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_121926c0ab1c3c37795c4fe4c4227c2a |
| publicationDate | 2011-08-31^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RS-51605-B |
| titleOfInvention | 3-PHENYL SUBSTITUTED PIRIDOINDOLONE, ITS MAKING AND THERAPEUTIC USE |
| abstract | Compound of Formula: wherein: - R 1 represents a hydrogen atom, a (C 1 -C 4) alkyl group or (CH 2) nOH, (CH 2) nO-tetrahydropyran-2-yl, (CH 2) n NR 7 R 7, (CH 2) nCN, (CH2) nCO2 (C1-C4) alkyl or (CH2) nCONR6R7 group; - R2 represents a hydrogen atom or (C1-C4) alkyl group; - or R1 and R2 together form a (CH2) 3 group; - R3 represents phenyl a group monosubstituted with hydroxyl, hydroxymethyl, carboxyl, (C1-C4) alkanoyl, azido, (C1-C4) alkoxycarbonyl, hydroxyiminomethyl, (C1-C4) alkylsulfonyl, trifluoromethyl, thiol, (C1-C4) alkylthio or cyano or CH2) mNR'7R10, CONR6R8 or O (CH2) nR9 group; a phenyl group substituted by 2 to 5 identical or different substituents selected from halogen atoms, (C1-C4) alkyl, trifluoromethyl, hydroxyl, hydroxymethyl, (C1-C4) alkoxy, carboxyl, (C1-C4) alkanoyl, azido, (C1- C4) alkoxycarbonyl, hydroxyiminomethyl, thiol, (C1-C4) alkylthio or (C1-C4) alkylsulfonyl group or phenyl or cyano group, or with a (CH2) mNR'7R10, CONR6R8 or O (CH2) nR9 group; or R3 represents a benzodioxolyl group which is unsubstituted or substituted on the phenyl group with a halogen atom; - R4 and R5 are identical or different and each independently represents a hydrogen or halogen atom or hydroxyl, (C1-C4) alkyl, trifluoromethyl, phenyl, cyano, ( A C1-C4 alkoxy, (C1-C4) alkoxycarbonyl or (C1-C4) alkylsulfonyl group or an O- (CH2) nNR6R7 or (CH2) nNR6R7 group; - R6 represents hydrogen or a (C1-C4) alkyl group; represents hydrogen or a (C1-C4) alkyl group; - or R6 and R7, together with the nitrogen atom to which they are attached, form a heterocyclic radical selected from: piperidyl, morpholinyl, pyrrolidinyl, piperazinyl or 4-methylpiperazin-1-yl; '6 represents hydrogen or a (C 1 -C 4) alkyl group; - R'7 represents hydrogen or a (C 1 -C 4) alkyl group; - or R'6 and R'7 together with the nitrogen atom to which they are attached form a heterocyclic radical selected from morpholinyl or pyrrolidinyl; - R8 represents hydrogen, (C1-C4) alkyl group or - (CH2) nNR6R7 group; - or R6 and R8, together with an atom to which they are attached form a heterocyclic radical selected from: piperidyl, morpholinyl, pyrrolidinyl, piperazinyl or 4-methylpiperazin-1-yl; - R 9 represents a phenyl radical or an amino, morpholin-4-yl, cyano or (C1-C4) alkoxy carbonyl group; - R10 represents R6 or a phenyl, pyridyl or pyrimidinyl group or (CH2) nNR'6R'7 group; - or R'7 and R10 together with the nitrogen atom to which they are attached form a heterocyclic radical selected from piperazinyl or 4-methylpiperazin-2-yl; - n represents 1, 2 or 3; - m represents 0 or 1; - Alk represents an alkyl group; in the basic form or in the form of a salt formed by the addition of an acid and in the form of a hydrate or solvate. patent claims. |
| priorityDate | 2002-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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