| abstract |
A compound of Formula (1) wherein Y and Z are independently selected from a) or b) such that one of Y and Z is selected from group a) and the other is selected from group b); C3-8 cycloalkyl optionally substituted with one to two fluoro substituents, iii) trifluoromethyl, or iv) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyrimidinyl, isoxazolyl, benzothienyl, thieno$3,2-b] thiophen-2-yl, pyrazolyl, triazolyl, tetrazolyl, and [1,2,3]thiadiazolyl; wherein the C6-10 aryl is substituted with; and the heteroaryl is optionally substituted with; by one substituent selected from the group consisting of fluoro, chloro, bromo, C1-4alkyl, C1-4alkoxy, cyano, C1-4alkylcarbonylamino, and trifluoromethyl; Group b) jei) C6-10aryl; ii) heteroaryl selected from the group consisting of thiazolyl, pyridinyl , indolyl, indazolyl, benzoxazolyl, benzothiazolyl, benzofuranyl, benzothienyl, 1H-pyrrolo$3,2-b]pyridin-5-yl, 1H-thieno$2,3-c]pyrazol-5-yl, 1H-pyrrolo$2,3- b]pyridin-5-yl, 1H-pyrazolo$3,4-b]pyridin-5-yl, furo$2,3-b]pyridin-2-yl, quinolinyl, quinazolinyl, furanyl, $1,2,3]triazolyl, thienyl, oxazolyl, 1,3,4]oxadiazol-2-yl, pyrrolyl, pyrazolyl, and benzimidazolyl; iii) 2,3-dihydro-1H-indolyl; iv) 2,3 diphenyl-indolyl; v) diphenyl-imidazolyl; vi) 1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yl; vii) 3-(4-chlorophenyl)-4,5,6,7-tetrahydro- indazol-2-yl; viii) 1-(4-fluorophenyl)-1H-pyrrolo[3,2-b]pyridin-6-yl; iiix) diphenyl-1H-pyrazol-3-yl; wherein each phenyl is optionally substituted with one to two chloro substituents; and wherein said pyrazolyl is optionally substituted with one methyl substituent; wherein C 6-10 aryl, 2,3-dihydro-1H-indolyl, and heteroaryl of Group b) are optionally independently substituted with one to two substituents selected from the group consisting of bromo , chloro, fluoro, iodo, C 1-4 alkyl, C 1-4 alkoxy, and trifluoromethyl; and are substituted with one additional substituent selected from the group consisting of i) C6-10aryl; ii) heteroaryl selected from the group consisting of pyrimidinyl, thienyl, quinolinyl, pyridinyl, isoxazolyl, thiazolyl, benzimidazolyl, pyrrolyl, furanyl, pyrimidinyl, and pyrazolyl; oriii) 5,6-dihydro-4H-cyclopentapyrazol-2-yl; wherein said heteroaryl and 5,6-dihydro-4H-cyclopentapyrazol-2-yl are optionally substituted with one phenyl substituent, and said phenyl substituent is optionally substituted with one to two chloro substituents or trifluoromethyl; and wherein the phenyl of C6-10aryl and heteroaryl are optionally independently substituted with one to two substituents selected from the group consisting of C1-4alkyloxycarbonylamino; C1-4 alkyl; cyanomethyl; C1-4Alkoxy; one to three fluoro or chloro substituents; trifluoromethyl; trifluoromethoxy; trifluoromethylthio; C1-4alkylcarbonyl; C1-4Alkoxycarbonyl; C1-4Alkoxycarbonyl(C2-4)alkenyl; cyano(C2-4)alkenyl; (2-cyano)ethylaminocarbonyl; cyano; carboxy; aminocarbonyl; C1-4alkylaminocarbonyl; di(C14alkyl)aminocarbonyl; formyl; nitro; bromo; hydroxy; di(C14alkyl)aminosulfonyl; C1-4alkylsulfonyl; di(C1-4alkyl)am |