| abstract |
1. A nucleic acid molecule that! (a) encodes a polypeptide consisting of! (aa) two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to! (ab) mature eukaryotic histone; ! (b) encodes a polypeptide consisting of! (ba) two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to! (bb) a mature eukaryotic polypeptide, the sequence of which is at least 80% identical to the sequence of the mature eukaryotic histone (a) and substantially retains its biological activity; or ! (c) hybridizes under stringent conditions with the complementary strand of a nucleic acid molecule encoding polypeptide (a) or (b), said nucleic acid molecule encoding a polypeptide that has at least two N-terminal methionine residues and substantially retains biological the activity of the polypeptide (a) or (b). ! 2. The nucleic acid molecule according to claim 1, where the histone is selected from the group consisting of histone H1.0, H1.1, H1.2, H1.3, H1.4, H1.5 and H1t. ! 3. A nucleic acid molecule that is complementary to a nucleic acid molecule according to claim 1 or 2.! 4. The antisense oligo- or polynucleotide of the nucleic acid molecule according to claim 1 or 2, which includes nucleotides complementary to triplets from nucleotides encoding the first two N-terminal methionine residues (ab), (bb) or (c), and has a minimum length component of 10 nucleotides. ! 5. A vector comprising a nucleic acid molecule according to claim 1 or 2.! 6. A host transformed by a vector according to claim 5, wherein the host is not human and is not |