http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2009145947-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C273-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C273-1854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C275-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C273-18 |
| filingDate | 2008-04-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-06-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2009145947-A |
| titleOfInvention | METHOD FOR SYNTHESIS (Z) -3- [2-BUTOXY-3 '- (3-HEPTIL-1-METHYLUREIDO) BIPHENYL-4-IL] -2-METHOXYACRYLIC ACID |
| abstract | 1. Method for the synthesis of (Z) -3- [2-butoxy-3 '- (3-heptyl-1-methylureido) biphenyl-4-yl] -2-methoxyacrylic acid of formula (I)! ! characterized in that the sulfonate of general formula (XII)! ,! where R2 means methyl, trifluoromethyl, phenyl or tolyl, reacted with 3-heptyl-1-methyl-1- [3- (4,4,5,5-tetramethyl [1,3,2] dioxaborolan-2-yl) phenyl] urea of formula (IIIb)! ! or with the corresponding boronic acid of the formula (IIIa)! ! 2. The method according to claim 1, characterized in that the reaction is carried out in the presence of a palladium or nickel catalyst. ! 3. The method according to claim 1 or 2, characterized in that the sulfonate of general formula (XII)! ! is obtained by saponification of an ester of general formula (XIII)! ! where R1 means alkyl. ! 4. The method according to claim 3, characterized in that the ester of the general formula (XIII)! ! is obtained by the interaction of alkyl (Z) -3- (3-butoxy-4-hydroxyphenyl) -2-methoxyacrylate of general formula (XIV)! ! with a compound selected from triflic anhydride, mesyl chloride, benzenesulfonyl chloride and tosyl chloride. ! 5. The method according to claim 4, characterized in that the alkyl (Z) -3- (3-butoxy-4-hydroxyphenyl) -2-methoxyacrylate of the general formula (XIV)! ! obtained by the Wittig reaction by the interaction of 3-butoxy-4-hydroxybenzaldehyde of the formula (XV)! ! with (methoxyalkoxycarbonylmethyl) -triphenylphosphonium halide of formula (XVII)! ! 6. Compound of general formula (XII)! ! where R2 means methyl, trifluoromethyl, phenyl or tolyl. ! 7. Compound of general formula (XIII)! ,! where R1 is alkyl and R2 is methyl, trifluoromethyl, phenyl or tolyl. ! 8. Compound alkyl (Z) -3- (3-butoxy-4-hydroxyphenyl) -2-methoxyacrylate of general formula (XIV)! ! where R1 means alkyl. |
| priorityDate | 2007-05-11^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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