http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010107599-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-0053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00 |
| filingDate | 2008-07-24^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-09-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010107599-A |
| titleOfInvention | ENZYMATIC METHOD FOR PRODUCING 17-MONOESTERS OF CORTEXOLON AND / OR THEIR 9,11-DEHYDRO DERIVATIVES |
| abstract | 1. A method of obtaining compounds of formula (I)! ! in which R represents a linear or branched aliphatic or aromatic chain containing from 1 to 10 carbon atoms, characterized in that the compound of formula II! ! in which R has the same meanings as above, are reacted with a compound of formula III! R'OH, (III)! In which R 'represents a linear aliphatic chain containing from 1 to 10 carbon atoms, in the presence of lipase from Candida. ! 2. The method of claim 1, wherein R is C1-C4 alkyl. ! 3. The method according to claim 1, in which R is selected from CH3, CH3CH2, CH3 (CH2) 2 or CH3 (CH2) 3. ! 4. The method according to claim 1, in which R 'is an aliphatic chain containing 1-8 carbon atoms. ! 5. The method according to claim 1, characterized in that it is carried out in the presence of an organic solvent, preferably aprotic. ! 6. The method according to claim 5, wherein said solvent is selected from toluene, acetonitrile, tetrahydrofuran, dichloromethane and / or chloroform. ! 7. The method according to claim 1, wherein said compound of formula II is present in an amount of from about 0.01 to 0.15 mol / L. ! 8. The method according to claim 7, in which the specified compound of formula II is present in an amount of 0.025 mol / L. ! 9. The method according to claim 1, wherein said compound of formula III is selected from methanol, ethanol, butanol and / or octanol. ! 10. The method according to claim 1, wherein said compound of formula III is present in an amount of from about 0.5 to about 50 moles per mole of the starting substrate. ! 11. The method according to claim 1, wherein said compound of formula III is present in an amount of 5 moles per mole of the starting substrate. ! 12. The method according to claim 1, in which the specified lipase from Candida selected from CCL and CALB. ! 13. The method according to claim 1, wherein said lipase from |
| priorityDate | 2007-08-03^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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