http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2010139461-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0446 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0451 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate | 2009-03-01^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-04-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2010139461-A |
| titleOfInvention | RGD- (BACTERIO) CHLOROFILL CONJUGATES FOR PHOTODYNAMIC THERAPY AND VISUALIZATION OF NECROTIC TUMORS |
| abstract | 1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and conjugate of an RGD-containing peptide or peptidomimetic RGD and a chlorophyll or bacteriochlorophyll photosensitizer, for minimally invasive tumor-targeted imaging, tumor-targeted photodynamic therapy (PDT) and / or interactive prognosis of necrotic tumors, wherein represents chlorophyll or bacteriochlorophyll of the formula I, II or III: !! where M represents 2H or an atom selected from the group consisting of Mg, Pd, Pt, Co, Ni, Sn, Cu, Zn, Mn, In, Eu, Fe, Au, Al, Gd, Dy, Er, Yb, Lu, Ga, Y, Rh, Ru, Si, Ge, Cr, Mo, P, Re, Tc and Tl and their isotopes and radioisotopes; ! X represents O or N-R7; ! each of R1, R'2 and R6 independently represents Y-R8, -NR9R'9 or -N + R9R'9R "9A-; or R1 and R6 in formula II together with the carbon atoms to which they are attached form a ring containing an RGD peptide or an RGD peptidomimetic;! Y is O or S;! R2 is H, OH or COOR9;! R3 is H, OH, C1-C12 alkyl or C1-C12 alkoxy;! R4 is —CH = CR9R '9, -CH = CR9Hal, -CH = CH-CH2-NR9R'9, -CH = CH-CH2-N + R9R'9R "9A-, -CHO, -CH = NR9, -CH = N + R9R' 9A-, -CH2-OR9, -CH2-SR9, -CH2-Hal, -CH2-R9, -CH2-NR9R'9, -CH2-N + R9R'9R "9A-, -CH2-CH2R9, -CH2- CH2Hal, -CH2-CH2OR9, -CH2-CH2SR9, -CH2-CH2-NR9R'9, -CH2-CH2-N + R9R'9R "9A-, -COCH3, C (CH3) = CR9R'9, -C ( CH3) = CR9Hal, -C (CH3) = NR9, -CH (CH3) = N + R9R'9A-, -CH (CH3) -Hal, -CH (CH3) -OR9, -CH (CH3) -SR9, -C H (CH3) -NR9R'9, -CH (CH3) -N + R9R'9R'9A- or -C≡CR9; ! R'4 represents methyl or formyl; ! R5 is O, S, N-R9, N + R9R'9A-, CR9R'9 or CR9-Hal; ! each of R7, R8, R9, R'9 and R ″ 9 independently represents:! (a) H;! (b) C1-C25 hydrocarbyl;! (c) C1-C25 hydrocarbyl, preferably C1-C25 alkyl, alkenyl or alkynyl more preferably C1-C10 or C1-C6 alkyl substituted with one or more functional groups selected from the group consisting of � |
| priorityDate | 2008-02-27^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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