| abstract |
1. A method for modulating the function and / or expression of a pyrroline-5-carboxylate reductase 1 polynucleotide (PYCR1) in a patient’s cells or tissues in vivo or in vitro, the method comprising: contacting said cells or tissues with at least one antisense oligonucleotide of length from 5 to 30 nucleotides, wherein said at least one oligonucleotide has a sequence of at least 50% identical to the sequence inversely complementary to a polynucleotide containing from 5 to 30 consecutive nucleotides in the range from 1 about 380 nucleotide sequence of SEQ ID NO: 2; with modulating, therefore, the function and / or expression of said polynucleotide pyrroline-5-carboxylate reductase 1 (PYCR1) in cells or tissues of a patient in vivo or in vitro. 2. A method for modulating the function and / or expression of a pyrroline-5-carboxylate reductase 1 polynucleotide (PYCR1) in a patient’s cells or tissues in vivo or in vitro, comprising: contacting said cells or tissues with at least one antisense oligonucleotide of at least 5 in length up to 30 nucleotides, wherein said at least one oligonucleotide has a sequence that is at least 50% identical to the sequence inversely complementary to the sequence of the natural antisense polynucleotide sequence irrolin karboksilatreduktazy-5-one (PYCR1); thus modulating the function and / or expression of said pyrroline-5-carboxylate reductase 1 polynucleotide (PYCR1) in cells or tissues of a patient in vivo or in vitro. 3. Method for modulating the function and / or expression of the pyrroline-5-carboxylate reductase 1 polynucleotide (PYCR1) in cells or tissues of a patient� |