http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2236412-C2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-02 |
| filingDate | 2002-07-18^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-09-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4813a91ee43749fd6079268b105c583b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60dfd23217e499187b901a7a1e64a4ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ac6baa942a668495038a6e5d2f440a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_309719a5c6ba47954f5525b39337515a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c15181303a11a9bc6cd68647312a438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5318cb18c08a3f91078ff0b1288cddae |
| publicationDate | 2004-09-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2236412-C2 |
| titleOfInvention | Method for preparing derivatives of morphinone, method for preparing derivatives of 14-hydroxymorphinone and method for preparing derivative of oxymorphone |
| abstract | FIELD: organic chemistry, chemical technology, medicine, narcology. n SUBSTANCE: invention relates to a method for preparing derivatives of morphinone that are intermediate compounds used for preparing derivatives of 14-hydroxymorphinone that, in turn, are used for preparing antagonists of opiates - derivatives of oxymorphone. Method for preparing derivatives of morphinone involves oxidation of derivatives of morphine of the general formula (I): n with hypochlorous and hypobromous acid salts wherein in indicated formula (I) R means lower alkyl, (C 3 -C 6 )-cycloalkyl, benzyl or substituted benzyl, cyano-group; R 1 means alkyl, benzyl or alkylcarbonyl; R 2 means hydrogen atom, alkyl, benzyl or alkylcarbonyl. Oxidation is carried out with hypochlorous and hypobromous acid salts prepared preferably before oxidation immediately. For oxidation sodium and potassium hypochlorites or hypobromites are used preferably. Antagonists of opiates are important medicinal agents used for treatment and diagnosis of narcomania. n EFFECT: improved preparing method, valuable medicinal properties of compounds. n 7 cl, 3 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2448709-C1 |
| priorityDate | 2002-07-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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