| abstract |
FIELD: organic chemistry, medicine, pharmacy. n SUBSTANCE: invention relates to compound of the formula (I): that are useful as antagonists of prostaglandin IP (I 2 or PGI 2 ). Invention proposes compound of the formula (I) wherein each R 1 , R 2 and R 3 means independently in each case aryl or heteroaryl; R 4 means -COOH or tetrazolyl; A, B, m, p, q, n and r are determined in the invention description. Also, invention relates to separated isomers, racemic or nonracemic mixtures of isomers and to their pharmaceutically acceptable salts or solvates also. Also, invention relates to pharmaceutical compositions comprising indicated compounds, to a method for their preparing and using as therapeutic agents. Invention provides the development of pharmaceutical composition possessing property of antagonists of IP wherein antagonists of these receptors can prevent states associated with excessive bleeding, for example, (but not only) hemophilia and hemorrhage and relieve septic shock-associated hypotension and diminish formation of edemas. n EFFECT: valuable medicinal properties of compounds. n 28 cl, 15 sch, 29 ex |