| abstract |
FIELD: organic chemistry, chemical technology, pharmacy. n SUBSTANCE: invention describes novel compounds of the general formula (I): wherein R 1 means quinolinyl possibly substituted with (C 1 -C 5 )-alkoxy-group, isoquinolinyl, quinoxalinyl, pyridinyl, pyrazinyl, benzyl possibly substituted with halogen atom, naphthalinyl, thiophenyl, furanyl, cinnolyl, phenylvinyl, quinolylvinyl or 4-oxo-4H-chromenyl possibly substituted with halogen atom, (C 1 -C 5 )-alkyl or (C 1 -C 5 )-alkoxy-group; R 2 , R 5 , R 8 and R 11 mean hydrogen atom; R 3 and R 4 mean halogen atom, (C 1 -C 5 )-alkoxy-group; R 6 and R 7 mean hydrogen atom (H) or (C 1 -C 5 )-alkyl or form in common radical -CH 2 -CH 2 -; R 9 and R 10 mean (C 1 -C 5 )-alkoxy-group; m and n mean a whole number from 0 to 4 independently; X means -CH 2 - or sulfur atom (S). Also, invention describes their pharmaceutically acceptable salts, a method for their preparing and pharmaceutical composition based on thereof. Proposed compounds are inhibitors of P-glycoprotein, enhance bioavailability of anti-cancer drug and can be used in medicine. n EFFECT: improved preparing method, valuable medicinal properties of compounds and pharmaceutical composition. n 7 cl, 3 tbl, 33 ex |