| abstract |
FIELD: medicine; pharmacology. n SUBSTANCE: invention refers to pharmaceutical formulation inhibiting protein kinase, containing inhibiting selective kinase compound amount of general formula (I): , where: R means aryl or indolyl, and the latter is optionally substituted with one or more groups selected from R 4 , -C(=O)-R, -C(=O)-OR 5 , -C(=O)-NY 1 Y 2 and -Z 2 R; R 2 means H; R 3 means H; R 4 means C 1 -C 6 alkyl, optionally substituted with one substitute -C(=O)-NY 1 Y 2 ; R 5 means H; R 7 means C 1 -C 6 alkyl; R means C 1 -C 6 alkyl; X 1 means C-aryl, C-heteroaryl, such as pyridile or isoxasolyl, and the latter is optionally substituted with one or two C 1 -C 6 alkyls, C-heterocycloalkyl, such as morpholinile or peperidynil, C-halogen, C-CN, C-OH, C-Z 2 R, C-C(=O)-OR 5 , C-NY l Y 2 , C-C(=O)-NY 1 Y 2 ; Y 1 and Y 2 means redardless H, aryl, C 3 -C 6 cycloaryl, C 1- C 6 alkyl, optionally substituted with one group selected from phenyl, halogen, heterocyclil, such as morpholinile, phurile, hydroxyl, -C(=O)-OR 5 , OR 7 ; or group-NY 1 Y 2 can form morpholinile, peperidynil, optionally substituted with one or two substitutes selected from OH, C 1 -C 6 alkyl; Z means O; where aryl as group or part of group means optionally substituted with one or two substitutes monocyclic aromatic C 6 carbocyclic fragment, where substitute is selected from halogen or C 1 -C 6 alkoxy, C(=O)-OR 5 ; except compounds: 4-chlorine-2-(4-tert-butylphenyl)-1H-pyrrole[2,3-b]pyridine, 2-(5-methoxy-1 -methyl-1 H-indole-3-il)-4-phenyl-1H- pyrrole[2,3-b]pyridine, 2-(5- methoxy-1 -methyl-1 H-indole-3-il)-1H- pyrrole[2,3-b] pyridine-4-carbonitrile, 4-chlorine-2-(5- methoxy-1 -methyl-1H-indole-3-il)-1H- pyrrole[2,3-b]pyridine, or 2-(5- methoxy-1H-indole-3-il)-1H- pyrrole[2,3-b]pyridine -4- carbonitrile. n EFFECT: application of compound for production of medicinal agent for inflammatory disease. n 51 cl, 9 tbl, 148 ex |