| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to new compounds with general formula (I) , where R 1 and R 2 are independently chosen from hydrogen, halogen, nitro, alkyl, alkylaryl and XYR 5 ; X and Y are independently chosen from O and (CR 6 R 7 ) n ; R 3 represents hydrogen, alkyl or M; M represents an ion, chosen from aluminium, calcium, lithium, magnesium, potassium, sodium, zinc or their mixture; Z represents CR 4 ; R 4 is chosen from hydrogen, halogen, alkyl, alkylaryl and XYR 5 ; R 5 is chosen from aryl, substituted aryl, heteroaryl and substituted heteroaryl; R 6 and R 7 are independently chosen from hydrogen and alkyl; n is an integer from 1 to 6; at least one of R 1 and R 2 represents XYR 5 , and at least one of X and Y represents (CR 6 R 7 ) n . The invention also pertains to the method of increasing concentration of D-serine and/or reducing concentration of toxic products of D-serine oxidation under the effect of DAAO in mammals, involving introduction into a subject of a therapeutically effective amount of a formula I compound, to the method of treating schizophrenia, treating or preventing loss of memory and/or cognitive ability, to the method of improving learning ability, method of treating neuropathic pain, as well as to a pharmaceutical composition, with DAAO inhibitory activity, based on these compounds. n EFFECT: obtained are new compounds and a pharmaceutical composition based on these compounds. n 27 cl, 4 tbl, 72 ex |