| abstract |
FIELD: chemistry. n SUBSTANCE: present invention relates to compounds with formula I: , in which: R 1 is R 6 C(O)-, HC(O)-, R 6 SO 2 -, R 6 OC(O)-, (R 6 ) 2 NC(O)-, R 6 -, (R 6 ) 2 NC(O)C(O)-; R 2 is a hydrogen atom, -CF 3 or R 8 ; R 3 is a hydrogen atom or (C1-C4)aliphatic group-; R 4 is -COOH; R 5 is -CH 2 F or -CH 2 O-2,3,5,6- tetrafluorophenyl; R 6 is (C1-C12)aliphatic or (C3-C10)cycloaliphatic group, (C6-C10)aryl-, (C3-C10)heterocyclyl-; and where R 6 is substituted with up to 6 substitutes, independently chosen from R; R is a halogen atom, OR 7 and -R 7 ; R 7 is (C1-C6)aliphatic group-, (C3-C10)cycloaliphatic group; R8 is (C1-C12)aliphatic- or (C3-C10)cycloaliphatic group; to a pharmaceutical composition with caspase-inhibiting activity, based on compound with formula I, to methods of treatment as well as to methods of inhibiting caspase-mediated functions and to a method of reducing production of IGIF or IFN-β. The invention also relates to a method of preserving cells, as well as to a method of producing compound with formula I. n EFFECT: new compounds are obtained and described, which can be used for treating diseases in the development of which caspase activity takes part. n 34 cl, 4 tbl, 43 ex |