| abstract |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel compounds of formula I , where R2 is selected from a group consisting of (1) phenyl, which is substituted with R2a, R2b and R2c, (2) furanyl, (3) C3-6 cycloalkyl; R2a, R2b and R2c are independently selected from a group consisting of (1) hydrogen, (2) halogen, (3) C1-6 alkyl, which is unsubstituted or substituted with (a) 1-6 halogen atoms, (4) -NR10R11, where R10 and R11 are hydrogen; R3 is C1-6 alkyl or C3-6 cycloalkyl, which is independently unsubstituted or substituted with 1-6 halogen atoms; R4 and R5 are hydrogen and m equals zero, R2 is directly bonded to a carbonyl; and to pharmaceutically acceptable salts thereof. The invention also pertains to compounds which are selected from the group, as well as a pharmaceutical composition. ^ EFFECT: obtaining novel biologically active compounds which are active as glycine transporter GlyT1 inhibitors. ^ 10 cl, 14 ex, 1 tbl |