http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2403243-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6042509de7544921c96de43b9da1438 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2006-05-02^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-11-10^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7d6d5667f2b2385086892f1d826d2c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d728ca3e8d16200625ca5584198b32a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14751d9a17f4d600a7fa566e90c12de2 |
| publicationDate | 2010-11-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2403243-C2 |
| titleOfInvention | 4-phenyl-5-oxo-1, 4, 5, 6, 7, 8-hexahydrochinoline derivatives as medications for treatment of infertility |
| abstract | FIELD: medicine, pharmaceutics. n SUBSTANCE: invention relates to novel derivatives of 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinoline, represented by formula , where R 1 represents (1-6C)alkyl; R 2 represents halogen, (1-4C)alcoxy; R 3 represents OH, NO 2 , CN, fluoridated with (1-4C)alkoxy, (1-4C)alkoxy(2-4C)alkoxy. hydroxy(2-4C)alkoxy, (1-4C)alkoxycarbonyl, R 7 , R 8 -amino, R 9 , R 10 -amino, R 9 , R 10 -aminocarbonyl, R 9 , R 10 -aminosulfonyl or phenyl(1-4C)alkoxy, where phenyl ring in composition phenyl(1-4C)alkoxy is optionally substituted with one or several substituents, selected from (1-4C)alkoxy; R 4 represents R 11 -phenyl or R 11 -(4-5C)heteroaryl, which represents heteroaromatic group, containing 4-5 carbon atoms and at least one heteroatom, selected from N and S, where phenyl or heteroaryl group is optionally additionally substituted with one or several substituents, selected from nitro, (1-4C)alkyl, (1-4C)alkoxy; R 7 represents H, (1-4C)alkyl; R 8 represents (1-4C)alkylsulfonyl, (1-4C)alkylcarbonyl, (1-4C)alkoxycarbonyl, (1-4C)alkoxy(1-4C)alkylcarbonyl, furylcarbonyl; phenyl(1-4C)alkylcarbonyl, where phenyl ring is optionally substituted with one or several substituents, selected from (1-4C)alkoxy; R 9 and R 10 are not necessarily selected from H, (1-6C)alkyl and (1-4C)alkoxy(2-4C)alkyl; or R 9 and R 10 can be bound together with formation of morpholinyl ring; R 11 represents H, R 12 , R 13 -amino, R 14 , R 15 -aminocarbonyl or R 14 , R 15 -aminosulfonyl; R 12 represents H; R 13 represents (1-4C)alkylsulfonyl, (1-4C)alkylcarbonyl, (1-4C)alkoxycarbonyl or pyperazinyl(1-4C)alkylcarbonyl; R 14 and R 15 are independently selected from H, (1-6C)alkyl, (1-4C)alkoxy(2-4C)alkyl and imidazolyl(1-4C)alkyl; X represents O or R 16 -N; Y represents CH 2 or C(O);Z represents CN; R 16 represents H, (1-4C)alkyl, (1-4C)alkylcarbonyl; or their pharmaceutically acceptable salts. Invention also relates to pharmaceutical composition, as well as to application of 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinoline derivatives by any of i.i. 1-10. n EFFECT: obtaining novel biologically active compounds, which possess agonistic activity with respect to FSH receptor. n 13 cl, 43 ex |
| priorityDate | 2005-05-04^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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