| abstract |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention refers to a new keratin-binding effector molecule containing polypeptide sequences which have binding affinity with keratin, to preparation and use thereof. An available keratin-binding domain (domain B) is the polypeptide sequence SEQ ID NO:1 position 2193-2481, as well as its functional equivalents. A further keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO:1 position 2606-2871, as well as its functional equivalents, the domains are meant as human desmoplakin domains. ^ EFFECT: invention provides high-specific affinity with skin keratin of a subject. ^ 17 cl, 41 ex, 8 dwg |