| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salts thereof, where Q is CH or N; R2 is C 1 -C 4 alkyl or C 3 -C 4 -cycloalkyl; Y is R5-O; where R5 is propynyl; X is selected from a group consisting of aryl, heteroaryl, C 1 -C 5 -alkyloxy, heterocycloalkyl, arylamino, heteroarylamino, heteroaryl-C 1 -C 4 -alkylamino, aryloxy, aryl-C 1 -C 2 -alkyloxy or C 3 -C 6 -cycloalkyl-C 1 -C 4 -alkyloxy, each of which is optionally substituted with 1-3 times; the optional substitute(s) for X is(are) independently selected from a group comprising halogen, cyano, trifluoromethyl, nitro, hydroxy, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkyloxy-C 1 -C 4 -alkoxy, -SMe, SO 2 -C 1 -C 2 -alkyl, -NMe 2 , - C(O)O-C 1 -C 5 -alkyl, -SCF 3 , -SO 2 -NH 2 , -SO 2 -C 2 -alkyl-OH, -CONH 2 , -COMe, - CONH-C 1 -C 4 -alkyl, -CONMe 2 , -NHCOMe, -CH 2 COOEt, -OCH 2 COOEt, -CH 2 - cyclopropyl, and each R3 and R4 is H; where aryl denotes phenyl or naphthyl; heteroaryl denotes monocyclic or bicyclic hydrocarbon containing 5-10 ring atoms, one or more of which are heteroatoms selected from O, N or S; heterocyclyl denotes piperidinyl or benzodioxolyl; or a compound or pharmaceutically acceptable salt thereof, selected from a group comprising (4-dimethylaminophenyl)-[4-(4-cyclopropylphenyl)-6-propargyloxyquinazolin-2-yl]methanone, (3-sulphamoylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, [3-(2-hydroxyethanesulphonyl)phenyl]amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, (3-methylsulphanylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, (3-methanesulphonylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, and (5-ethanesulphonyl-2-hydroxyphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4- dihydroquinazoline -2-carboxylic acid. The invention also relates to a pharmaceutical composition based on the compound of formula (I) and use of the compound of formula (I). n EFFECT: novel benzoquinazoline derivatives, which are useful in treating bone disorders, are obtained. n 6 cl, 128 ex |