http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2425045-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 2006-12-14^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-07-27^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78fffec39c87e5a523a618894b950ad8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf501dc3ad4bb895a97b6257984d1cab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb160f22616d2c3cd46e95919d2d8093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ef233ceb893d69d324edb83d6562ae1 |
| publicationDate | 2011-07-27^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2425045-C2 |
| titleOfInvention | Aryl-isoxazole-4-yl-imidazole derivatives |
| abstract | FIELD: medicine, pharmaceutics. n SUBSTANCE: present invention refers to aryl-isoxazole-4-yl-imidazole derivatives of formula I and to their pharmaceutically acceptable acid addition salts. The compounds of the present invention exhibit GABA A α5 receptor binding site activity and selectivity. In general formula I n each of R 1 -R 3 independently represents hydrogen atom or halogen atom; R 4 represents hydrogen atom, lower alkyl, C 3 -C 7 cycloalkyl, -(CH 2 ) n -O-lower alkyl or hydroxy substituted lowest alkyl; R 5 represents -(CH 2 ) m -phenyl or -(CH 2 ) m -(5-6-members heteroaryl with 1-2 heteroatoms independently seected from N, O) which optionally substituted by one or more substitutes selected from a group consisting of halogen atom, cyano, nitro, lower alkyl, lower alkoxy, lower alkylsulphanyl, lower alkyl substituted by halogen atom, -C(O)-lower alkyl, -C(O)-O-lower alkyl, -NH-C(O)-O-lower alkyl or -C(O)-NH-R' where R' represents the lower alkynyl or hydroxy substituted lower alkyl, or represents -(CH 2 ) n -C 3 -C 7 -cycloalkyl, -(CH 2 ) n -(6-members heterocyclyl with 1-2 heteroatoms selected from N, O), -(CH 2 ) n -(5-6-members heteroaryl with 1-2 heteroatoms selected from N, O) or -(CH 2 ) n -phenyl optionally substituted by halogen atom; R 6 represents hydrogen atom, -C(O)H, -(CH 2 ) n -O-lower alkyl, -C(O)O-lower alkyl, lower alkyl substituted by hydroxy or halogen atom, or represents C 3 -C 7 -cycloalkyl, phenyl, or represents -(CH 2 ) n -O-CH 2 -phenyl optionally substituted by halogen atom or lower alkyl, or represents -(CH 2 ) n -O-CH 2 -(6-members heteroaryl with 1 heteroatom selected from N) optionally substituted by lower alkyl or lower alkyl substituted by halogen atoms, or represents -(CH 2 ) n -NH-(CH 2 ) o -(6-members heterocyclyl with 2 heteroatoms selected from N; n means 0, 1, 2 or 3; m means 0 or 1; o means 1, 2 or 3. n EFFECT: presented preparation of a drug containing one or more compound of formula I and application of the compounds for preparing the drug. n 31 cl, 168 ex |
| priorityDate | 2005-12-27^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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