| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to new compounds of formula (IB) or to their pharmaceutically acceptable salts: n , wherein R means formula: R 1 means -C(O)NR 3 R 4 , -C(O)R 3 and -C(O)OR 3 ; each R 3 and R 4 independently means H, C 1-10 alkyl, wherein alkyl is optionally substituted by one -OH; R 3 and R 4 are bound together with N atoms to form a 5-6-member heterocyclic ring which additionally contains one O heteroatom; R 5 means H; R 6 means CN; R 7 means H; W means C. What is described is a method for producing both them and intermediate compounds of formula (1-1c): , wherein: R 1 means -C(O)NR 3 R 4 ; R 3 and R 4 are specified above. n EFFECT: compounds (IB) shows DPP-IV inhibitory activity that allows them being used in a pharmaceutical composition. n 9 cl, 12 ex |