http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2475448-C2

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filingDate 2008-12-22^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-02-20^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f41c7ed76a6ae52bc861bca55dee4748
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publicationDate 2013-02-20^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2475448-C2
titleOfInvention Method of treating fluoride
abstract FIELD: chemistry. n SUBSTANCE: invention relates to a method of producing a [ 18 F]fluoride solution, involving: (1) bringing a [ 18 F]fluoride solution in water into contact with a cryptand bound to a solid support of formula (I): linker-cryptand (I), at pH lower than 5, to form a cryptand-[ 18 F]fluoride complex of formula (II): solid support-linker-cryptand 18 F - (II), removing excess water from the cryptand-[ 18 F]fluoride complex of formula (II); (3) washing the cryptand-[ 18 F]fluoride complex of formula (II) with a solution of a base having pKa of at least 9 in order to free [ 18 F]fluoride into the solution. The invention also relates to a [ 18 F]radiofluorination method using said technique, as well as a compound and apparatus for realising said method. n EFFECT: invention provides an efficient method of treating [ 18 F]fluoride which enables rapid trapping and elution of [ 18 F]fluoride from water which contains a target. n 11 cl, 3 ex
priorityDate 2008-01-03^^<http://www.w3.org/2001/XMLSchema#date>
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