http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2476427-C2
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f83ac68f68cfabd0fd5daf622d775ad4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D255-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-417 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 |
| filingDate | 2008-04-23^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-02-27^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee6f7a31a29456618d1d274cf1eaac4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93d954e24426c6857b94fd923a04764c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b54984043ca7c057c86a5c767310515c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45496810747ef75c6f3ac848d3028b79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5444cddea20e23c1363711c5795cbe6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f76be904dd9ac594cadfd9370c4ed74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7a31b83bf5f4586d13c8b312176e0bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a83f98ea4756dea209aa1d14dbe08008 |
| publicationDate | 2013-02-27^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2476427-C2 |
| titleOfInvention | Dual-acting antihypertensive compounds, methods for preparing them, based pharmaceutical compositions and intermediate compounds |
| abstract | FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to new compounds of formula (I) and to their pharmaceutically acceptable salts wherein r represents 1; Ar is specified inand, Ris specified in -COOR, -NHSOR, -SONHR, -SOOH, -O-CH(R)-COOH and tetrazol-5-yl, Rrepresents H, -Calkyl, -Calkylenaryl, -Calkyleneheteroaryl, - Ccycloalkyl, -CH(Calkyl)OC(O)R, orRrepresents -O-Calkyl or -O-Ccycloalkyl; Rrepresents R; Rrepresents -Calkyl or -Calkylenaryl; Rrepresents -C(O)Ror -C(O)NHR; Rrepresents -Calkyl; Y represents -C(R)-, Z represents -N-, Q represents -C(R)-, and W represents a bond; Y represents -N-, Z represents -C(R)-, Q represents -C(R)-, and W represents a bond; Y represents -C(R)-, Z represents -N-, Q represents -N-, and W represents a bond; or Y represents -C(R)-, Z represents -CH-, Q represents -C(R)-, and W represents -C(O)-; Ris specified in H, halogen, -Calkyl, -Cdicloalkyl, and -Calkylene-OR; wherein Ris specified in H and -Calkyl; Ris specified in -Calkyl and -Calkylene-O-Calkylene-R; and Rrepresents -Calkyl; X represents -Calkylene-, where at least one group -CH- in alkylene is substituted by the group -NR-C(O)- or -C(O)-NR-, wherein Ris specified in H, -OH, and -Caalkyl; Ris specified in -Calkylene-SR, -Calkylene-C(O)NRR, -Calkylene-NR-C(O)R, -NH-Calkylene-P(O)(OR)2, -Calkylene-CHR-COOH and -Calkylene-C(O)NR-CHR-COOH; Rrepresents H or -C(O)-R; Rrepresents -Calkyl, -Calkylene-Ccycoalkyl, -Calkylenaryl, or -Calkylenemorpholine; Rrepresents -OH, -OC(O)R, -CHCOOH or -OC(S)NRR; Rrepresents -Calkyl, -OCH-aryl or -CHO-aryl; Rand Rindependently represents -Calkyl; Rrepresents H; Rrepresents H; Rrepresents H; Rrepresents H or -CH-O-(CH)-O-CH; Rrepresents H; Rrepresents -Calkylenaryl; Ris specified in -Calkyl, -Calkylenaryl, -Calkyleneheteroaryl and -Calkylene-Ccycloalkyl; and Rrepresents H or together with Rto form -Ccycloalkyl; where each ring in Ar and each aryl and heteroaryl in Rand Rare optionally substituted by 1-3 substitutes optionally specified in -Calkyl, -CN, halogen, -O-Calkyl, -phenyl, -NO, wherein each alkyl is optionally substituted by 1-5 fluorine atoms; each carbon atom in X is optionally substituted by one or more groups R, and one group -CH- in X may be substituted by -Ccycloalkylene- and -CH=CR-; where Ris specified in -C-5alkylene-COORand benzene, where Rrepresents H; and Rrepresents -CH-thiophen; each alkyl and each aryl in R, Rand Rare optionally substituted by 1-7 fluorine atoms; where aryl represents monovalent aromatic hydrocarbon having one ring or condensed rings, and contains 6-10 carbon atoms in the ring; and heteroaryl represents a monovalent aromatic group having one ring or two condensed rings, and having 5-10 atoms in large in the ring with one atom of the ring represents a heteroatom specified in nitrogen, oxygen and sulphur. Besides, the invention refers to a pharmaceutical composition based on the compound of formula,to a method for preparing the compound of formula (I), to intermediate compounds used in synthesis of the compound of formula (I), to the use of the compounds of formula (I).EFFECT: there are prepared new compounds possessing activity of a type 1 angiotensin II (AT) receptor antagonist and activity of neprilysin inhibition.38 cl, 36 ex |
| priorityDate | 2007-04-24^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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