| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: present invention refers to pharmaceutics and represents a pharmaceutical composition for preventing and treating osteoporosis, administered once a month and containing: (a) cholecalciferol granules, wherein (i) cholecalciferol in an amount of 24000-50000 IU; (ii) one or more ingredients specified in tocopherol acetate, butylated hydroxy toluene and butylated hydroxy anisole as a first stabilizing agent; and (iii) a binding agent adsorbed on microcrystalline cellulose, (b) mannitol as a second stabilizing agent, and (c) risedronic acid or its salt or ibandronic acid or its salt. n EFFECT: invention provides the cholecalciferol timing stability and the size reduction of the produced preparation. n 14 cl, 9 ex, 5 tbl |