http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2550821-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ada8e6c3e2d23ae50da43485d76cdc0e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 |
| filingDate | 2010-10-29^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a57420d9f3f1051dbea2d931aa2b0441 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e76ccc48f21fd748e72ada30a2c6710e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_075a8b4a0cf309741db532e51a9022c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee6a0af17862eb7e94dc44c8631df618 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_730dcd1d4a5d10916983bcf9a1259f6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfc6e102530cb4646d78144a897b4ec7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d392a87463e31b209b9710484a65c336 |
| publicationDate | 2015-05-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2550821-C2 |
| titleOfInvention | Bicyclic pyridines and analogues as sirtuin modulators |
| abstract | FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, namely to a compound of formula(I), or its tautomer, or a pharmaceutically acceptable salt, where each of Zand Z: N and CR, where at least, one of Zand Zrepresents CR, and each R: H, C-Calkyl and -N(R)(R); W: -O-, -N(C-C) alkyl and -C(R)(R) -, and each R: H and C-Calkyl, or two R, bound with the same carbon atom, are taken together with the formation of =O, R: a phenyl and heterocycle, which represents a saturated or unsaturated 5-6-member monocyclic ring, containing 1-3 heteroatoms, selected from atoms N, S and O, or a 8-12-member bicyclic ring, each cycle of which is selected from a saturated, unsaturated and aromatic cycle, containing 1-2 nitrogen atoms, where Ris optionally substituted with one or more substituents, independently selected from halogen, C-Calkyl, =O, fluorosubstituted C-Calkyl, -O-R, -(C-Calkyl)-N(R)(R), -N(R)(R) and -C(O)-N(R)(R), R: a phenyl and heterocycle, which represents an unsaturated 5-6-member monocyclic ring, containing 1-2 heteroatoms, selected from atoms N and O, or represents dihydrobenzofuranyl, where Ris optionally substituted with 1-2 substituents, independently selected from a halogen, -C?N, C-Calkyl, C-Cfluorosubstituted alkyl, -O-R, -(C-Calkyl)-N(R)(R) and -N(R)(R); each R: -C-Calkyl; or two Rare taken together with a nitrogen atom, which they are bound with, with the formation of a 4-8-member unsaturated heterocycle, optionally containing one additional heteroatom, selected from N and O, where in case when Rrepresents an alkyl, the said alkyl is optionally substituted with two -OH groups, and when two Rare taken together with a nitrogen atom, which they are bound with, with the formation of a 4-8-member saturated heterocycle, the said saturated heterocycle is optionally substituted with fluorine by any carbon atom; and is substituted with hydrogen by any capable of substitution nitrogen atom; p equals 1, 2 or 3; Xis selected from -C(=O)-?, -C(=O)-O-?, -C(=O)-NH-?, -S(=O)-NH-? and -C(=O)-NH-CRR-?, where: ? represents a site, by which Xis bound with R; and each Rand Rrepresents hydrogen. The invention also relates to compounds of formulas(IV),(V),(VI), particular the compounds, a pharmaceutical composition based on the compound of formulas (I), (IV)-(VI) and to a method of treatment, based on the application of the said compounds.EFFECT: novel heterocyclic compounds, possessing sirtuin-modelling activity are obtained.26 cl, 2 tbl, 40 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11203595-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2758256-C2 |
| priorityDate | 2009-10-29^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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