| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to compounds of formula , wherein R 1 represents methyl or ethyl, R 2 represents hydrogen, fluorine or methyl, R 3 represents hydrogen, fluorine or methyl, each R 4 represents hydrogen and R 5 represents hydrogen, methyl. The invention also refers to a pharmaceutical composition for treating or relieving a degree of severity of a proliferative disorder by means of compounds of formula (I). n EFFECT: compounds are effective in preparing a drug for treating or reducing a degree of severity of metastatic cancer, glioblastoma, gastric carcinoma or cancer specified in colon cancer, breast cancer, prostate cancer, cerebral cancer, liver cancer, pancreatic cancer or lung cancer and hepatocellular carcinoma. n 16 cl, 4 tbl, 6 ex |