| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention relates to the field of pharmaceutics and represents a method of treating a patient with locally advanced or metastasising solid tumours, which includes the introduction of a therapeutic combination as a combined composition or by the alternation of components to a mammal, with the therapeutic composition including a therapeutically effective quantity of phosphatidylinositol-3-kinase (PI3K) or its pharmaceutically acceptable salt, and a therapeutically effective quantity of an inhibitor of a mitogen-activated proteinkinase kinase (MEK) or its pharmaceutically acceptable salt. n EFFECT: invention provides a synergic effect in the combined application of active agents in the treatment of locally advanced or metastasising solid tumours. n 5 cl, 7 ex, 2 tbl, 7 dwg |