http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2607081-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ed67ffc797261e25e36f93e838cd8d8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 |
| filingDate | 2013-04-24^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-01-10^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b2f709d7ba170753cf75a4b771e4fc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da07ae4673734ba1de6f91ac3593ecd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dee8136abf411468c53a595acd23429 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95dea3b95b7a70d24891ef6421950fe9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d65714b5dd02eca768a97d75c3ee90f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b088a5a830e84de8834a77258923ec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cd5ab79f5f90091cc13cb8f61db96d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4d446bc5aafd90888d5cb57aa9971f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f450778c3364c12af58f8025675a12e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7db3c17f91c40ecca1d3a20bb3c27355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4cd7fe81258a00046cbf284d143a3e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fa66bec890b589443fb77aa4d3f8baf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_114fe15ab081d2a69a681b3b71bb449b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a800b38f3c1e18cf0701535a5e2111a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0eed5222ad3bfe51557a671f86b5fd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_775dc0a237ba576970383f3587e06fa3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_172a70f248eed1cb5fbc89e72bab00f2 |
| publicationDate | 2017-01-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2607081-C2 |
| titleOfInvention | Sulfonamide derivative and medicinal use thereof |
| abstract | FIELD: chemistry; pharmaceutics. n SUBSTANCE: invention relates to novel sulfonamide derivatives of general formula (1) or pharmaceutically acceptable salts thereof, possessing the properties of inhibition integrin α4β7. In general formula (1) (1), A means a group presented by general formula (2-1) or (2-2) , where Arm is a 5- or 6-member aromatic ring, containing 0, 1 or 2 heteroatoms, selected from nitrogen atoms, R 1 and R 11 , each, independently, represents any substitute selected from a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group, mono- or di-lower alkylamino group, R 12 , R 13 and R 14 , each, independently, represents any substitute selected from a hydrogen atom, lower alkyl group, lower alkoxy group, amino group, lower alkylamino group, low di(alkyl)amino group or (lower alkylamino)lower alkyl group, R 2 and R 3 , each, independently, represents any substitute selected from a hydrogen atom, lower alkyl group or lower alkoxy group, B is represents any substitute selected from lower alkoxy group, optionally substituted by hydroxyl group, lower alkyl group, mono- or di-lower alkylamino group; C 3 -C 6 cyclic alkoxy group and/or 6-member(s) heterocyclic(s) group (groups) with an oxygen atom, sulphur atom or a nitrogen atom as heteroatom, hydroxyl group, R 41 is represents a hydrogen atom or lower alkyl group, a, b, c and d, each, independently, represents C-R 31 , C-R 32 , C-R 33 and C-R 34 respectively, but one or two of a, b, c and d, each, can be a nitrogen atom, R 31 , R 32 , R 33 and R 34 , each, independently, represents any substitute selected from a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group, provided that any R 31 , R 32 , R 33 and R 34 represents a halogen atom or lower alkyl group, e, f, g and h, each, independently, represents C-R 35 , C-R 36 , C-R 37 and C-R 38 respectively, however, one or two of e, f, g and h, each, can be a nitrogen atom, R 35 , R 36 , R 37 and R 38 , each, independently, represents any substitute selected from a hydrogen atom, lower alkyl group or lower alkoxy group, D represents a phenyl group or a 5 -or 6-member aromatic heterocyclic group, containing a nitrogen atom, an oxygen atom or sulphur atom, optionally containing a substitute(s), selected from a group consisting of hydroxyl groups, lower alkyl groups, lower alkoxy groups, E is a 5- or 6-member heterocyclic group with 1-4 heteroatoms, selected from nitrogen atoms, an oxygen atom and sulphur atom in the cycle, optionally containing a substitute(s), selected from a group consisting of halogen atoms, hydroxyl groups, lower alkyl groups, lower alkoxy groups, amino groups, 4- or 6-member cyclic amino groups, carboxyl groups and lower alkoxy-carbonyl groups; aminocarbonyl group, optionally containing a substitute(s) selected from the group, consisting of hydroxyl groups, lower alkyl groups, lower alkoxy groups, 5- or 6-member heterocyclic groups, containing 1, 2, 3 or 4 heteroatoms, selected from a group consisting of oxygen atoms, sulphur atoms and nitrogen atoms as a component(s) ring atom(s), and substituted by heterocycle of lower alkyl groups, where heterocycle means a 5- or 6-member heterocyclic groups, containing 1, 2, 3 or 4 heteroatoms, selected from group consisting of oxygen atoms, sulphur atoms and nitrogen atoms as a component(s) ring atom(s); hydrogen atom, hydroxyl group, lower alkyl group, lower alkoxy group, amino group, lower alkyl-carbonyl group, lower alkyloxy-carbonyl group or a lower alkylaminoalkilen group, and provided that the lowest alkyl-carbonyl group and the lowest alkyloxycarbonil group can be, each of which, are connected to a phenyl group, presented D, to form condensed ring. n EFFECT: compounds can be used for treating or preventing an inflammatory disease, in which the pathological condition associated with indirect by integrins α4β7 adhesion process. n 15 cl, 2 tbl, 258 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2667520-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2667520-C9 |
| priorityDate | 2012-04-24^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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