| abstract |
FIELD: pharmacology. n SUBSTANCE: invention relates to organic chemistry, namely a heterocyclic compound of formula (I) or to a therapeutically acceptable salt thereof, where X is benzo[d]thiazolyl, thiazolo[5,4-b]pyridinyl, thiazolo[4,5-c]pyridinyl, imidazo[1,2-a]pyridinyl, thiazolo[5,4-c]pyridinyl, thiazolo[4,5-b]pyridinyl, imidazo[1,2-a]pyrazinyl or imidazo[ 1,2-b]pyridazinyl; Y 1 means pyrrolyl, pyrazolyl, triazolyl or pyridinyl; where Y1 is optionally substituted with 1 or 2 substituents independently selected from R 5 , CN and Cl; L 1 is selected from (CR 6 R 7 ) q , (CR 6 R 7 ) s -O-(CR 6 R 7 ) r , (CR 6 R 7 ) s -S-(CR 6 R 7 ) r , (CR 6 R 7 ) s -S(O) 2 -(CR 6 R 7 ) r and (CR 6 R 7 ) s -NR 6A -(CR 6 R 7 ) r ; Y 2 means mono- or tricyclic C 8 -C 10 -cycloalkyl, spiro[2.5]octyl, spiro[3.5]nonyl, oxatricyclo[3.3.1.1 3,7 ]decyl or azabicyclo[3.2.1]octyl; where Y 2 is optionally substituted with 1, 2 or 3 substituents independently selected from R 8 , OR 8 , SO 2 R 8 , CO(O)R 8 , OH and Br; Z 1 is selected from , R 1 and R 3 are absent; R 2 is deuterium or C 1 -C 6 -alkyl; R 5 is C 1 -C 6 -alkyl; R 6A is selected from hydrogen and C 1 -C 6 -alkyl; each R 6 and R 7 are hydrogen; R 8 is selected from the group consisting of C 1 -C 3 -alkyl, morpholinyl and dioxydothiomorpholinyl; where R 8 , meaning C 1 -C 6 -alkyl, is optionally substituted with a substituent selected from R 16 , OR 16 , SO 2 R 16 and NHR 16 ; R k is selected from C 1 -C 6 -alkyl, morpholinyl, cyclopropyl and C 1 -haloalkyl; R 16 Is selected from C 1 -C 4 -alkyl, phenyl, morpholinyl and tetrahydropyranyl; where R 16 , meaning C 1 -C 4 -alkyl, is optionally substituted with 1 substituent selected from OCH 3 , OCH 2 CH 2 OCH 3 and OCH 2 CH 2 NHCH 3 ; q is 1 or 2; s, m and p is 0; r is 0 or 1; N is 0, 1, or 2. The invention also relates to specific compounds, pharmaceutical compositions based on these compounds and a method for treatment of these diseases. n EFFECT: new heterocyclic compounds are obtained, that are useful for treatment of some cancers. n 16 cl, 3 tbl, 86 ex |