| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a novel bicyclic or tricyclic heterocyclic compound of formula (I, where ring A is an optionally substituted aromatic group, one of X 1 and X 2 is a carbon atom, and other is nitrogen atom, X 3 is a nitrogen atom or CR 2 , X 4 is a nitrogen atom or CR 3 , X 5 represents a sulphur atom or -CH = CH-, Z 1 is an oxygen atom, -C(R 6 )(R 7 )-, -NH-, -C(R 6 )(R 7 )-NH-, -NH-C(R 6 )(R 7 )-, -C(R 6 )(R 7 )-O-, -OC(R 6 )(R 7 )- or a single bond, one of Z 2 and Z 3 is CH, and the other is a nitrogen atom, or both are nitrogen atoms, and other symbols have values defined in the description of invention, or its pharmacologically acceptable salt. n n n n EFFECT: compound has inhibitory action on Kynurenine Aminotransferase-II (KAT-II), and can be used to produce a medicinal agent for treating cognitive impairment, neurodegenerative disease or schizophrenia. n 22 cl, 3 tbl, 728 ex |