| abstract |
FIELD: pharmaceuticals.SUBSTANCE: invention relates to a compound of formula (I):where: ♦ R1denotes a phenyl group or a thienyl group, ♦ R2denotes a hydrogen atom or a halogen atom, n denotes an integer equal to 0, 1 or 2, ♦ J represents a -C(O)- group, -CH(R3)- group or -SO2- group, ♦ R3represents a hydrogen atom or a linear or branched (C1-C6)alkyl group, ♦ K represents a bond or -Cy1- group, ♦ L represents a -Cu2group or -CH2-Cy2group, ♦ W represents a groupwhere:■representsor,■ X represents carbon atom or a nitrogen atom, ■ R4represents a hydrogen atom, a halogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, -Y1-NR6R7group, -Y1-OR6group, a linear or branched halogen (C1-C6)alkyl group, an oxo group, -Y1-Cu3group, -Cy3-R7group, -Cy3-OR7group, or -Y1-NR6-C(O)-R7group, ■ R5represents a hydrogen atom, a halogen atom, or a linear or branched (C1-C6)alkyl group, ■ R6is a hydrogen atom or a linear or branched (C1-C6) alkyl group, ■ R7is a hydrogen atom, a linear or branched (C1-C6)alkyl group or -Y2-Cy4group, ■ Y1and Y2independently represent a bond or a linear or branched (C1-C4)alkylene group (values of the remaining radicals see paragraph 1 of formula), which is a USP7 protein activity inhibitor, as well as pharmaceutical compositions and combinations containing said protein.EFFECT: novel (hetero)aryl-substituted piperidinyl derivatives, a method for preparing them and pharmaceutical compositions containing them are disclosed.32 cl, 1 tbl, 1013 ex |