http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2742663-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e0bf0928b608797b70bbc2b91c7e52e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B43-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-20 |
| filingDate | 2016-05-10^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-09^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c472fd8773c6405ad4697b41612e68a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a807214276953645c8bc4f6bb04697b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dafae0c5b09c03f9cb9fc05bb1780def http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afd4c87ea6840865e03dd10a85b4d4b4 |
| publicationDate | 2021-02-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2742663-C2 |
| titleOfInvention | Method of producing 4-aminopyridazines |
| abstract | FIELD: chemistry.SUBSTANCE: invention relates to a method of producing a pyridazinamine compound of formula V or a salt thereof, a tautomer or an N-oxide. Method includes a step of reacting (a) a dichloropyridazinamine compound of formula IVa or a salt thereof, a tautomer or N-oxide, or (b) a dichloropyridazinamine compound of formula IVb or a salt thereof, a tautomer or N-oxide, or (c) mixture (a) and (b) with hydrogen in the presence of a hydrogenation catalyst. Method further includes a step of producing (a) a dichloropyridazinamine compound of formula IVa or a salt thereof, a tautomer or N-oxide, or (b) a dichloropyridazinamine compound of formula IVb or a salt thereof, tautomer or N-oxide, or (c) mixture (a) and (b) by a reaction involving steps of reacting a compound of formula II with POCl3and reacting the obtained crude reaction product with an amino compound R1-NH2or a salt thereof. Formed in situ 3,4,5-trichloropyrazine is directly reacted with an amino compound to obtain desired dichloropyridazinamine compounds, stage of extraction of trichloropyrazine compound is passed and trichloropyridazine is transferred into organic phase and is directly used at the next reaction stage. In compounds of formulas IV, IVa and VR1is H, C1-C2-alkyl or C1-C2-alkoxy-C1-C2-alkyl. Invention also relates to a method of producing (a) a dichloropyridazinamine compound of formula IVa or a salt thereof, a tautomer or N-oxide, or (b) a dichloropyridazinamine compound of formula IVb or a salt thereof, a tautomer or N-oxide, or (c) a mixture of (a) and (b). Method includes steps of reacting a compound of formula II with POCl3and reacting the obtained crude reaction product with an amino compound R1-NH2or a salt thereof.EFFECT: no need to add a base as an additional chemical; possibility of repeated use of hydrogenation catalyst without its purification, high yields of the product.9 cl, 1 ex |
| priorityDate | 2015-05-11^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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