http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SI-20874-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-06 |
| filingDate | 2001-06-05^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e5ca600c4959b9f2df2dedf0dc321f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce17cb5cf42b5921f4e485a73091794f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a521ada9d18f825fb80ec2055f24398 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f187e44aa689acb025d9665c0bf9a7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d25ba8f5a3cc28f95825823a755fad05 |
| publicationDate | 2002-10-31^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SI-20874-A |
| titleOfInvention | A process for the preparation of optically active derivatives of 2- (6- (hydroxy-methyl) -1,3-dioxan-4-yl) acetic acid |
| abstract | The present invention provides manufacturing technology that can produce optically active 2- (6- (hydroxymethyl) -1,3-dioxan-4-yl) acetic acid derivatives, which are important pharmaceutical intermediates, from inexpensive and readily available starting materials without using any special device such as an ultra low temperature reactor. The present invention is a manufacturing process for an optically active derivative of 2- (6-hydroxymethyl) -1,3-dioxan-4-yl) acetic acid, comprising the reaction of an enolate, prepared by allowing the base or 0-valent metal to act per acetic acid ester derivative, with (S) -beta-hydroxy-gamma-butyrolactone at a temperature not lower than -30 degrees Celsius, to obtain a dihydroxyohexanoic acid derivative, treating it with an acylating agent in the presence of a base to produce monoacyl derivative of dihydroxyhexanoic acid, reduction of this compound by a microorganism to produce a monoacyl derivative of trihydroxyhexanoic acid, treatment of this compound with an acetal-forming reagent in the presence of an acid catalyst to produce an acyloxymethyldioxinyl acid derivative. ŕ |
| priorityDate | 2000-06-05^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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