| abstract |
A novel process intermediate, tetrahydro-4- 3-(4-fluorophenyl)thiophenyl-2H-pyran-4-carboxamide, of the formula: <CHEM> is described, as well as its use in a process of preparing 5-lipoxygenase inhibitors of the formula: <CHEM> which comprises establishing a reaction mixture consisting of: <CHEM> - and - an electron deficient monocyclic or benzo-fused bicyclic N-heterocycle containing two nitrogen atoms of the formula: <CHEM> in an aprotic solvent; in the presence of a carbonate of the formula: (M)2-CO3, where M is an alkali metal, Group 1/Ia element, selected from the group consisting of lithium, Li; sodium,Na; potassium, K; rubidium, Rb; and cesium, Cs; followed by heating of said reaction mixture under a nitrogen atmosphere; whereby there is produced the desired compound of the above-recited formula. |