| abstract |
The present invention provides an ether derivative of the following formula (I), the pharmaceutical acceptable salt or the pharmaceutical acceptable ester thereof having excellent immunologic inhibition activity, [wherein, R1 and R2 maybe the same or different, each represents a hydrogen atom etc.; R3 represents a hydrogen atom etc.; R4 represents a lower alkyl group; n represents an integer of 0-4; X represents ethylene group, -E-C H2- etc.; Y represents a C1-C10 alkylene group etc.; R5 represents a substituted aryl group etc.; R6, R7, R8 and R9 maybe the same or different, each represents a hydrogen atom etc.], and a pharmaceutical composition which containing, as the active component, the compound, the pharmaceutical acceptable salt or the pharmaceutical acceptable ester or the other derivative thereof. |