abstract |
The invention is concerned with novel aza-pyridopyrimidinone derivatives of formula (1) wherein R1, R2, R3, R4, R5, X1, X2, X3, Y, Z, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments. |