| abstract |
The group of the present invention provides compounds of formula I: , Or its N-oxide, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: (R 1 ) a , (R 2 ) b , (R 3 ) c , L, A, and E is as described herein; the method of preparing the compounds, N-oxides or salts; the method for preparing the intermediates of the compounds, N-oxides or salts; and the compounds, N-oxides Or a salt composition; and their use for the treatment of M4-mediated (or M4-related) disorders including, for example, Alzheimer's Disease, schizophrenia (such as his cognitive and negative symptoms) , Pain, addiction and sleep disorders. |