| abstract |
The invention relates to a method for the manufacture of a compound of Formula I as mentioned above, or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising: reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: where in the above formulae A is the anion of an acid, LG is a leaving group, and n and m are integers, e.g. 1, 2 or 3 so that the compound of the formula II is electrically uncharged. The preceding reactions include reacting a compound of the formula VIII with a compound of the formula IX to yield the compound of the formula VII according to the following reaction scheme: The moieties are as defined in the description and claims. The reaction products of acids with the compound of the formula I, as well as the resulting products and specific forms/modifications thereof, are also inventions. |