| abstract |
Ortho-substituted benzoylguanidines of the formula I in which R(1) is H, F, Cl, Br, I, (C1-C4)-alkyl, CF3, imidazolyl, or (C4-C6)-cycloalkyl, R(2) and R(3) independently of each other are defined like R(1), and R(4) is (C1-C3)-alkyl, F, Cl, Br, I, CN or -(CH2)o-(CF2)o-CF3, n is zero or 1, o is zero, 1 or 2, as well as pharmaceutically tolerated salts thereof, are described. Compounds I have no undesirable salidiuretic properties, but have very good antiarrhythmic properties. They are outstandingly suitable for use as antiarrhythmic pharmaceuticals having a cardioprotective component for the prophylaxis and treatment of infraction as well as for the treatment of angina pectoris, the compounds also inhibiting or strongly reducing, in a preventive manner, the pathophysiological processes in association with the occurrence of ischemically induced damage. On account of their protective effects against pathological hypoxic and ischemic situations, the compounds of the formula I according to the invention can be used, as a consequence of inhibition of the cellular Na<+>/H<+> exchange mechanism, as pharmaceuticals for treating all acute or chronic damage elicited by ischemia, or diseases which are primarily or secondarily induced thereby. |