| abstract |
An ortho-substituted benzoylguanidine of the formula I, in which R(1) is hydrogen, trifluoromethyl or tert-butyl; R(2) is hydrogen or acetoxy; R(3) is halogen, methoxy, trifluoromethyl, tert-butyl or acetoxy; R(4) is hydrogen, halogen or methoxy; R(5) is hydrogen, halogen or methoxy, or its pharmaceutically tolerable salts. The said compounds are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and for infarct treatment and also for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes in the formation of ischemically induced damage, in particular in the illicitation of ischemically induced cardiac arrhythmias. |