http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-467900-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_233f66631ee1039fa63edc749d7f15e3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-02 |
| filingDate | 1995-05-16^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-12-11^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c050b0399aa85a8e830bca6783d1767e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_764e8c37bd1de4ee0ec27733eee3002e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e2fd7abf98e1d9e5a50c6ce02899ac8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3592095a3ce78819cd8df87aeb4e9f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_286ac5430332762c890eb19b6bc2cdac |
| publicationDate | 2001-12-11^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-467900-B |
| titleOfInvention | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation |
| abstract | A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula I, wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl, and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl, and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not hydrido; further provided that R4 is not phenyl optionally substituted at a substitutable position with one or more radicals selected from halo, C1-C6 alkylthio, C1-C6 alkylsulfonyl, cyano, nitro, C1-C6 haloalkyl, C1-C6 alkyl, hydroxyl, C2-C6 alkenyl, C1-C6 hydroxyalkyl, carboxyl, C3-C7 cycloalkyl, C1-C6 alkylamino, C1-C6 dialkylamino, C1-C6alkoxycarbonyl, aminocarbonyl, C1-C6 alkoxy, C1-C6 haloalkoxy, sulfamyl and amino; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not aralkenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof. |
| priorityDate | 1994-11-14^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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