http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I230154-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 |
| filingDate | 2001-06-26^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-04-01^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d383a743044966807d4315b323b6905 |
| publicationDate | 2005-04-01^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | TW-I230154-B |
| titleOfInvention | Process for the preparation of quinoline derivatives |
| abstract | Compounds of formula I, wherein R1 is hydrogen or chlorine and R2 is hydrogen, C1-C8alkyl, or C1-C8alkyl substituted by C1-C6alkoxy or by C3-C6alkenyloxy, can be prepared by (a) introducing the major portion of the amount to be reacted of a compound of formula II, into a solvent mixture comprising at least one organic solvent capable of forming an azeotrope with water, and at least one aprotic-dipolar solvent; (b) metering in an aqueous strong base in an amount equivalent to that major portion of the total amount of the compound of formula II; (c) adding the remaining portion of the amount to be reacted of the compound of formula II; (d) adding a weak base in an amount that is at least equivalent to that remaining portion; (e) removing the water from the reaction mixture by azeotropic distillation; (f) adding a compound of formula III, wherein R2 is as defined for formula I; and (g) isolating the resulting compound of formula I from the reaction mixture. |
| priorityDate | 2000-06-28^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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