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filingDate 2016-06-29^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-10-30^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-10-30^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10111943-B2
titleOfInvention Alphavirus replicon particles matched to protein antigens as immunological adjuvants
abstract The immune response to an antigen of interest, especially one in purified form, can be significantly enhanced by the simultaneous administration of an alphavirus replicon particle which expresses the same antigen. This allows for the use of significantly smaller quantities of the protein antigen than in conventional immunization strategies, and this new immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.
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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226399947
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID48543
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID24749
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC0K3N5
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1148
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100793057
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID11039
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7YS71
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID59300
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID48544
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID48543
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO77762
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID280824
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226399946
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID11036
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID12110
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID48544
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC0K3N4
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID11309
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP31817
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID633
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID11020
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID11033
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP55030
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID9793
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID44158
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID11034
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID11024
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9MZR8
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID10029
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID11039
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID1491
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID547985
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP51492
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3S4V6
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100128998

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