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filingDate 2017-02-13^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-08-13^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa52d8b644465110b8680e945ffdb8bf
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publicationDate 2019-08-13^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10376563-B1
titleOfInvention Methods for systemically delivering polypeptides and microorganisms therefor
abstract Methods and microorganisms for systemically introducing a polypeptide in the bloodstream of a subject. The methods of the invention include administering into the gastrointestinal tract of a subject a bacterium configured to express and produce and release the polypeptide. The bacterium is administered in an amount effective to introduce the polypeptide in the bloodstream of the subject, preferably in a detectable amount. The microorganisms of the invention include lactic acid bacteria, such as Lactobacillus reuteri, that comprise a recombinant gene configured to express a polypeptide to be systemically introduced.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP81277
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID16992
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP07885
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP18109
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP27359
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3772480
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2247
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID19701
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID395725
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO02837
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID12985
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO70615
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID403993
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID2107
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID281192
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID24179
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO71150
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID280888
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP10154
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID42061
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID280901
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO97513
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO71070
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID404002
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID44122
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID45845
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2688

Showing number of triples: 1 to 1000 of 1710.

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