Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-54 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
filingDate |
2017-02-13^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2019-08-13^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa52d8b644465110b8680e945ffdb8bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef613d7231a6e702fc49c2b0e10adad6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f793b0167bc0864b701f7415e0bfcce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_298ab18b196f7a4961ac419b33d2f73e |
publicationDate |
2019-08-13^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-10376563-B1 |
titleOfInvention |
Methods for systemically delivering polypeptides and microorganisms therefor |
abstract |
Methods and microorganisms for systemically introducing a polypeptide in the bloodstream of a subject. The methods of the invention include administering into the gastrointestinal tract of a subject a bacterium configured to express and produce and release the polypeptide. The bacterium is administered in an amount effective to introduce the polypeptide in the bloodstream of the subject, preferably in a detectable amount. The microorganisms of the invention include lactic acid bacteria, such as Lactobacillus reuteri, that comprise a recombinant gene configured to express a polypeptide to be systemically introduced. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020068936-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020030419-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10898552-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021087195-A1 |
priorityDate |
2016-02-12^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |